TCRN Practice Exam 2025 – Complete Prep for Your Test

Acute intoxication with cocaine and methamphetamines is indeed associated with seizures due to their stimulant properties and effects on the central nervous system. Both of these substances increase the release of neurotransmitters such as dopamine and norepinephrine, which can lead to hyperexcitability of neurons. This hyperexcitability can precipitate seizures during intoxication, especially if high doses are consumed or if the individual has underlying vulnerabilities.

In contrast, while alcohol and opioids can cause significant central nervous system depression, it is more commonly in situations of withdrawal from these substances rather than acute intoxication that seizures are seen. Similarly, marijuana and sedatives generally do not produce seizures during intoxication; rather, they tend to have calming effects. Lastly, nicotine and hallucinogens are not typically associated with seizures during acute use, as nicotine can lead to activation but not usually seizure activity, and hallucinogens typically cause altered perceptions without eliciting seizures acutely.